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About

A clinically tested epigenetic anti-ageing serum based on patented Age Clock Technology with higly concentrated active ingredient Epicelline® proven to visibly reverse 10 signs of ageing* for visibly younger skin and activate skin longevity. *Clinical studies over 2 weeks and 4 weeks with 43 volunteers respectively. Clinical study with 60 volunteers applying the product twice daily over 8 weeks.
NART: 99122-09900-28

Our breakthrough anti-age innovation  

The Hyaluron-Filler + Longevity Epigenetic Serum is formulated with highly concentrated Epicelline® to reverse signs of skin ageing visibly. 

Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing. 

After 17 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: 

Epicelline® helps to reactivate the skin’s youth genes  and allows skin cells to act younger. This mechanism makes the skin look younger than its age and reverses 10 signs of ageing, visibly leading to:  

  • Wrinkles reduction
  • Firmness increase
  • Lifting effect
  • Facial contours sharpened
  • Fine line reduction
  • Hydration
  • Rejuvenation
  • Radiance
  • Smoothness
  • Evenness

Disclaimer: Clinical studies over 2 weeks and 4 weeks with 43 volunteers respectively. Clinical study with 60 volunteers applying the product twice daily over 8 weeks.

How to Use

Apply the serum as the first step in the morning and evening. For advanced efficacy with 3x power, combine with the Eucerin Epigenetic Day and Night Care.

Main findings

*Product-in-use test with 400* and 160 ** volunteers over 4 weeks. ***Clinical study with 60 volunteers applying the product twice daily over 8 weeks. Biological age determined using age clock technology
100%
Confirm deep skin rejuvenation*
98%
Confirm reduced wrinkles**
98%
Confirm younger-looking skin**
100%
Confirm: The best skin I ever had*
100%
Confirm: reverses signs of aging*

Clinical Formula

Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

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Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
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4.4
from 177 reviews*
Write Review
    08/03/2026
    Hyaluron filler serum
    Lovely stuff would definitely buy again go grab some.
    Debs
    Originally posted on boots.com
    01/02/2026
    Allergy
    I had an allergic reaction! My skin turned red and was itchy!
    Ana Paula
    Originally posted on boots.com
    21/01/2026
    BEST SERUM ANTI-AGE
    I am using it first time, one week in and my skin is loving it! I combined with the dual serum anti-pigment and I can see a noticeable reduction in the wrinkles and skin texture.
    Sabrina
    Originally posted on boots.com
See all
*Reviews are not verified for authenticity
Eucerin Hyaluron-Filler

Hyaluron-Filler + Longevity Epigenetic Serum

  • 4.4
    177 reviews
Skin concerns
Ageing skin
Key Benefits
  • Visible results in 4 weeks* *Product-in-use test with 400 and 160 volunteers over 4 weeks.
  • Provides deep skin rejuvenation
  • Reduces wrinkles
  • Provides younger-looking skin
Read More
Key Ingredients

Dihydromyricetin (Epicelline®), Glycine Saponin, Enoxolone

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Size
30 ml
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