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An innovative dual-action serum with Thiamidol and concentrated Hyaluronic Acid

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Popular Searches
  • 10
  • 10%
  • 10% cream
  • 10% urea
  • 100
Popular Products
Hyperpigmentation
An innovative dual-action serum with Thiamidol and concentrated Hyaluronic Acid

Anti-Pigment Dual Serum for all skin types

30 ml
4.0 263 Reviews
Buy now
Blemish-prone-skin
Eucerin DermoPurifyer

DermoPurifyer Triple Effect Serum

40 ml
4.2 153 Reviews
Buy now
View All Products
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We take responsibility. For your skin. And our planet.

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About

A clinically tested epigenetic anti-ageing serum based on patented Age Clock Technology with active ingredient Epicelline® proven to visibly reverse signs of skin ageing for firmer, younger-looking skin. *Product-in-use test with 160 women over 4 weeks.
NART: 99122-09900-00

Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing.  

After 15 years of epigenetic research, Eucerin has harnessed the latest advancements in epigenetic science and discovered how to reactivate these youth genes based on a patented Age Clock Technology: Epicelline® reactivates the skin’s youth genes at the root and allows skin cells to act younger, promoting a youthful and revitalised complexion. This mechanism works at a cellular level to rejuvenate the skin and enhance its overall health.  

The serum reverses 10 signs of ageing by using Hyaluronic Acid, Enoxolone and Glycine Saponine to visibly plump the skin and help support the skin’s functions, resulting in firmer skin with enhanced contours, as well as reduced wrinkles and fine lines. By addressing multiple aspect of skin ageing, Eucerin Hyaluron-Filler Epigenetic Serum offers a holistic approach to enhancing and preserving your skin’s youthful radiance.  

This powerful serum gives a boost of hydration to help even and smooth out the skin, leaving your skin feeling radiant and rejuvenated at a cellular level, allowing you to enjoy a visibly younger and healthier complexion. 

Disclaimer: Clinical study over 2 and 4 weeks with 43 volunteers respectively. Product-in-use test over 4 weeks over 160 volunteers.

Main findings

*Product-in-use test with 160 women over 4 weeks.
98%
reduced wrinkles
99%
firmer-looking skin
98%
younger-looking skin
98%
rejuvenates skin
99%
provides healthy-looking skin
97%
skin feels immediately hydrated

Ingredients

We choose all our ingredients with great care and never compromise on quality. Learn more about the key ingredients of this product.

The ingredients in our brand products are updated regularly. For this reason, occasionally there may be discrepancies between the ingredients on our website and on our product packaging. We therefore recommend that you always pay attention to the information on our product packaging and check the ingredients listed there.

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  • Epicelline

    After analysing more than 50,000 substances, Eucerin scientists discovered Epicelline®, an innovative active ingredient that reactivates the skin’s youth genes at the root by making skin cells act younger.

  • Hyaluronic acid

    Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

    Learn More
  • Glycine Saponin

    Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

    * Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

    Learn More
  • Glycyrrhetinic Acid

    Glycyrrhetinic acid (also called Enoxolon) is derived from the roots of Glycyrrhiza glabra (licorice plant) and is well-known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti-inflammatory and antimicrobial properties.

    Glycyrrhetinic acid helps to preserve the level of hyaluronic acid and elastin against enzymatic degradation by hyaluronidase. Furthermore supports the skin's own repair mechanism against UV-induced DNA damage.

    Learn More

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100 years of history and innovative science for high-quality skincare that works. To make you feel good and enjoy life to the fullest, discover the life-changing power of dermatological skincare.

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Eucerin Hyaluron-Filler

Eucerin Hyaluron-Filler Epigenetic Serum

  • 4.5
    171 reviews
Skin concerns
Ageing skin
Key Benefits
  • Containing the powerful active ingredient Epicelline®, which reactivates the skin’s youth genes at the root and makes skin cells act younger
  • Formulated with Hyaluronic Acid to hydrate the skin and plump up wrinkles
  • Stimulates the skin's own Hyaluronic Acid, Collagen and Elastin production through the ingredient Glycine Saponin
  • Created with Enoloxone to reduce Hyaluronic Acid degradation and promote DNA repair
  • Clinical studies of the Eucerin Hyaluron-Filler Epigenetic Serum confirm visible results in 4 weeks of using the serum
Read More
Key Ingredients

Epicelline, Hyaluronic acid, Glycine Saponin

Learn More
Size
30 ml
Find a pharmacy
4.5
from 171 reviews*
Write Review
    25/04/2025
    Good
    The product delivers what it promises, my skin feels softer and my pores are smaller. My skin is firmer and silkier. I loved the result.
    Juliana
    Originally posted on boots.com
    10/04/2025
    10 stars
    I am so impressed with this serum. It doesn’t cause irritation and my fine lines seem to have disappeared. My skin feels plumped and rejuvenated. I’m on my second bottle and I’m so happy with it that I won’t bother buying retinol products any more. I highly recommend this.
    Mondaine
    Originally posted on boots.com
    08/04/2025
    A lovely serum
    I have enjoyed using Eucerin Hyaluron-Filler Epigenetic Serum. The texture is lightweight and absorbs rapidly without leaving any residue. It provides a lovely boost of hydration to my skin, making it feel smoother and revitalized. I also appreciate how well it layers under moisturizer and makeup. Overall, it has been a wonderful enhancement to my skincare routine! As for the packaging, the glass bottle feels premium and looks stunning. The fragrance is subtle and fresh, not at all overwhelming, which I truly value in skincare products.
    emmac298_8556
    Sample: Free sample provided
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*Reviews are not verified for authenticity