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About

An Epigenetic Day Care SPF 30 enriched with Epicelline®, based on patented Age Clock Technology, proven to visibly reverse the signs of ageing for younger‑looking skin, while helping to protect against advanced skin ageing.
NART: 99628-09900-00

Our breakthrough anti-age innovation  

Anti-ageing Day Care SPF 30, reverses signs of skin ageing visibly and protects against advanced skin ageing.

Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing.  

After 15 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: 

Epicelline® helps to reactivate the skin’s youth genes and allows skin cells to act younger. This mechanism makes the skin look younger than its age and reverses 10 signs of ageing, visibly leading to:  

  • Wrinkles reduction
  • Firmness increase
  • Lfiting effect
  • Pores
  • Fine line reduction
  • Hydration
  • Rejuvenation
  • Radiance
  • Smoothness
  • Evenness

Disclaimer: Clinical study over 2 weeks with 42 volunteers and clincal studies over 4 weeks with 40 and 52 volunteers respectively. 

How to Use

Apply the Day Care SPF 30 as the first step in the morning. For advanced efficacy with 3x power, combine with the Eucerin Epigenetic Serum and Night Care.

BUILD YOUR OWN SKIN PROTOCOL

Deep Rejuvenation
Apply the Hyaluron‑Filler + Longevity Epigenetic Serum morning and evening to a thoroughly cleansed face. Apply to the face, neck and décolleté, gently massaging into the skin.
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Prevent Photoaging
In the morning, apply 1–2 pumps of the Hyaluron‑Filler + Longevity Epigenetic Day Care SPF 30 to the face, neck and décolleté, gently massaging into the skin.
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Overnight Regeneration
Apply the Hyaluron-Filler + Longevity Epigenetic Night Care in the evening on your face, neck and décolleté by gently massaging it into the skin.
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Main findings

*Product-in-use test with 400* and 160 ** volunteers over 4 weeks. *** Product-in-use test with 400 volunteers over 4 weeks
100%
Confirm deep skin rejuvenation*
98%
Confirm reduced wrinkles**
98%
Confirm youger-looking skin**
100%
confirm lifting-effect on skin after 4 weeks***

Clinical Formula

Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

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Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

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Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

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Dihydromyricetin (Epicelline®)
An innovative active ingredient that helps to reactivate the skin’s youth genes by making skin cells act younger. 
Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

Learn More
Dihydromyricetin (Epicelline®)
An innovative active ingredient that helps to reactivate the skin’s youth genes by making skin cells act younger. 
Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

Learn More
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FAQ

What is epigenetics and how does it affect the skin?

Epigenetics explores how genes operate and how one’s lifestyle influences them, ultimately leading to signs of skin ageing. After 15 years of research, Eucerin scientists have found that these epigenetic changes determining your skin age can be reversed through targeted epigenetic skincare solutions.

What is Eucerin’s patented Age Clock Technology?

Patented Age Clock Technology is a novel algorithm based on the epigenetic patterns of young and aged skin, which can measure the skin’s biological age. This groundbreaking technology also enabled Eucerin scientists to discover the active ingredient Epicelline®.

What age should I start using the Epigenetic Day Care SPF 30?

While skin ages differently depending on genetics and lifestyle, signs of ageing typically begin to appear in the late twenties and early thirties. This is why we recommend starting to use the Epigenetic Day Care SPF 30 at this stage.

Can I apply the Epigenetic Day Care SPF 30 to the entire face or only to specific areas?

The Day Care SPF 30 can be applied liberally to the entire face, neck and décolleté. Avoid contact with the eyes.

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Photoageing

Photoageing Control Sun Fluid SPF50

4.3
from 58 reviews*
Write Review
    11/08/2026
    Great daytime skincare
    Overall I liked this moisturiser. I have really oily skin so before I tried this I wouldn’t bother using moisturiser in the morning because it would make my skin oily and destroy my makeup. However, I haven’t had the same problem with this. I do pack on a little extra setting powder, but I think it’s worth doing it for the skincare benefits. With the SPF30 I’ve also not burnt when out all day in the sun, although I do wish it was SPF50. I’m not sure I’ve noticed all the anti-aging effects they claim, but in general my skin looks good so I can’t complain!
    Review photo 1
    Acasa8
    Sample: Free sample provided
    11/08/2026
    Eucerin Hyaluron-Filler
    The cream has a rich lightweight consistency that spreads smoothly on skin without leaving greasy residue. It absorbs quickly giving the skin the glow everyone is looking for. I am absolutely in love with it, plus that I can use it under my makeup as it doesn’t peel off like other creams. Highly recommend this!
    Review photo 1
    Otilia136
    Sample: Free sample provided
    09/08/2026
    Great for everyday use
    I quite like this day cream as an every day cream. I found it absorbed quickly into my skin and felt light and non greasy. My skin was left feeling softer and smoother. I applied it once a day in the morning and found it sat well under makrup. It had an added bonus of having SPF in it too. I can not really comment if it helped reduce the signs of aging skin as I did not really notice a difference, it may need to be used over a longer period to see noticeable signs.
    Review photo 1
    AllyBee1
    Sample: Free sample provided
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*Reviews are not verified for authenticity
Hyaluron-Filler + Longevity

Hyaluron-Filler + Longevity Epigenetic Day Care SPF30

  • 4.3
    58 reviews
Skin concerns
Sun ProtectionAgeing skin
Key Benefits
  • Visibly reverses 10 signs of ageing
  • Provides long‑lasting, deep hydration
  • Helps protect against advanced skin ageing for younger‑looking skin
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Key Ingredients

Dihydromyricetin (Epicelline®), Hyaluronic acid, Glycine Saponin

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Size
50 ml
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