Sustainability & Environment

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We are committed to continually improving the environmental footprint of our products.
Environmental Impact
Compared to other face care products sold in the European market
Together with over 70 cosmetics companies & associations we have developed a science-based environmental impact assessment and scoring system.  Products that score “A” rank amongst the best in class of the face care category for having a lower environmental impact. Products that score “E” have a higher impact and are therefore key products to focus our efforts to improve their environmental performance.
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About

A clinically tested epigenetic anti-ageing serum based on patented Age Clock Technology with active ingredient Epicelline® proven to visibly reverse signs of skin ageing for firmer, younger-looking skin. *Product-in-use test with 160 women over 4 weeks.
NART: 99122-09900-00

Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing.  

After 15 years of epigenetic research, Eucerin has harnessed the latest advancements in epigenetic science and discovered how to reactivate these youth genes based on a patented Age Clock Technology: Epicelline® reactivates the skin’s youth genes at the root and allows skin cells to act younger, promoting a youthful and revitalised complexion. This mechanism works at a cellular level to rejuvenate the skin and enhance its overall health.  

The serum reverses 10 signs of ageing by using Hyaluronic Acid, Enoxolone and Glycine Saponine to visibly plump the skin and help support the skin’s functions, resulting in firmer skin with enhanced contours, as well as reduced wrinkles and fine lines. By addressing multiple aspect of skin ageing, Eucerin Hyaluron-Filler Epigenetic Serum offers a holistic approach to enhancing and preserving your skin’s youthful radiance.  

This powerful serum gives a boost of hydration to help even and smooth out the skin, leaving your skin feeling radiant and rejuvenated at a cellular level, allowing you to enjoy a visibly younger and healthier complexion. 

Disclaimer: Clinical study over 2 and 4 weeks with 43 volunteers respectively. Product-in-use test over 4 weeks over 160 volunteers.

Main findings

*Product-in-use test with 160 women over 4 weeks.
98%
reduced wrinkles
99%
firmer-looking skin
98%
younger-looking skin
98%
rejuvenates skin
99%
provides healthy-looking skin
97%
skin feels immediately hydrated

Clinical Formula

Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

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Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

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Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Epicelline

After analysing more than 50,000 substances, Eucerin scientists discovered Epicelline®, an innovative active ingredient that reactivates the skin’s youth genes at the root by making skin cells act younger.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
Epicelline

After analysing more than 50,000 substances, Eucerin scientists discovered Epicelline®, an innovative active ingredient that reactivates the skin’s youth genes at the root by making skin cells act younger.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid is derived from the roots of Chinese licorice plants. It inhibits the Hyaluronic Acid degradating enzyme Hyaluronidase (HYAL1) and therefore the degradation of skin‘s own Hyaluronic Acid by more than 50%.

Learn More
View all

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4.4
from 176 reviews*
Write Review
    01/02/2026
    Allergy
    I had an allergic reaction! My skin turned red and was itchy!
    Ana Paula
    Originally posted on boots.com
    21/01/2026
    BEST SERUM ANTI-AGE
    I am using it first time, one week in and my skin is loving it! I combined with the dual serum anti-pigment and I can see a noticeable reduction in the wrinkles and skin texture.
    Sabrina
    Originally posted on boots.com
    26/10/2025
    It's okay - not the best....
    its okay....have been using this for a few months now and unfortunately, i don't really think it is anything special. It goes on well, not too thick and absorbs really quickly, doesn't feel sticky and sits well under the moisturiser. Haven't seen any massive difference or improvements in the smile line wrinkle which i have, but it's not got any worse either. I think there are other products on the market which give the same, if not better results for less money. I really do think this product is extremely expensive for what it is.
    Sweet25
    Originally posted on boots.com
See all
*Reviews are not verified for authenticity
Eucerin Hyaluron-Filler

Eucerin Hyaluron-Filler Epigenetic Serum

  • 4.4
    176 reviews
Skin concerns
Ageing skin
Key Benefits
  • Containing the powerful active ingredient Epicelline®, which reactivates the skin’s youth genes at the root and makes skin cells act younger
  • Formulated with Hyaluronic Acid to hydrate the skin and plump up wrinkles
  • Stimulates the skin's own Hyaluronic Acid, Collagen and Elastin production through the ingredient Glycine Saponin
  • Created with Enoloxone to reduce Hyaluronic Acid degradation and promote DNA repair
  • Clinical studies of the Eucerin Hyaluron-Filler Epigenetic Serum confirm visible results in 4 weeks of using the serum
Read More
Key Ingredients

Epicelline, Hyaluronic acid, Glycine Saponin

Learn More
Size
30 ml
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