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About

A clinically tested epigenetic anti-ageing serum based on patented Age Clock Technology with higly concentrated active ingredient Epicelline® proven to visibly reverse 10 signs of ageing* for visibly younger skin and activate skin longevity. *Clinical studies over 2 weeks and 4 weeks with 43 volunteers respectively. Clinical study with 60 volunteers applying the product twice daily over 8 weeks.
NART: 99122-09900-28

Our breakthrough anti-age innovation  

The Hyaluron-Filler + Longevity Epigenetic Serum is formulated with highly concentrated Epicelline® to reverse signs of skin ageing visibly. 

Skin ageing is accelerated by lifestyle and environmental factors that change the skin’s epigenetic patterns. This means that youth genes are deactivated, leading to visible signs of ageing. 

After 17 years of epigenetic research, Eucerin has discovered how to reactivate these youth genes based on a patented Age Clock Technology: 

Epicelline® helps to reactivate the skin’s youth genes  and allows skin cells to act younger. This mechanism makes the skin look younger than its age and reverses 10 signs of ageing, visibly leading to:  

  • Wrinkles reduction
  • Firmness increase
  • Lifting effect
  • Facial contours sharpened
  • Fine line reduction
  • Hydration
  • Rejuvenation
  • Radiance
  • Smoothness
  • Evenness

Disclaimer: Clinical studies over 2 weeks and 4 weeks with 43 volunteers respectively. Clinical study with 60 volunteers applying the product twice daily over 8 weeks.

How to Use

Apply the serum as the first step in the morning and evening. For advanced efficacy with 3x power, combine with the Eucerin Epigenetic Day and Night Care.

BUILD YOUR OWN ACNE PRONE SKIN PROTOCOL

Deep Rejuvenation
Apply the Hyaluron‑Filler + Longevity Epigenetic Serum morning and evening to a well‑cleansed face. Apply to the face, neck and décolleté, gently massaging into the skin.
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Prevent Photoaging
In the morning, apply 1–2 pumps of the Hyaluron‑Filler + Longevity Epigenetic Day Care SPF 30 to the face, neck and décolleté, gently massaging into the skin.
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Overnight Regeneration
Apply the Hyaluron‑Filler + Longevity Epigenetic Night Care in the evening to the face, neck and décolleté, gently massaging into the skin.
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Main findings

*Product-in-use test with 400* and 160 ** volunteers over 4 weeks. ***Clinical study with 60 volunteers applying the product twice daily over 8 weeks. Biological age determined using age clock technology
100%
Confirm deep skin rejuvenation*
98%
Confirm reduced wrinkles**
98%
Confirm younger-looking skin**
100%
Confirm: The best skin I ever had*
100%
Confirm: reverses signs of ageing*

Clinical Formula

Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

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Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

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Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

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Dihydromyricetin (Epicelline®)
An innovative active ingredient that helps to reactivate the skin’s youth genes by making skin cells act younger. 
Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
Dihydromyricetin (Epicelline®)
An innovative active ingredient that helps to reactivate the skin’s youth genes by making skin cells act younger. 
Learn More
Glycine Saponin

Glycine Saponin, also known as Glycine Soja Germ Extract, is an active ingredient extracted from the soya bean. It is one of the most effective stimulators of Hyaluronic Acid in cells in the dermal layer of skin and has been proven to increase Hyaluronic Acid production by up to 256% on cell level*.

* Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

Learn More
Enoxolone

Enoxolone, also known as Glycyrrhetinic Acid, is derived from the roots of Glycyrrhiza glabra (liquorice plant) and is well known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti‑inflammatory and antimicrobial properties. 

Enoxolone helps preserve levels of Hyaluronic Acid and elastin by protecting them against enzymatic degradation by hyaluronidase, and supports the skin’s own repair mechanisms against UV‑induced DNA damage.

Learn More
Hyaluronic acid

Hyaluronic Acid is formed by skin cells and is part of the connective tissue of the skin. One of its key functions is to retain moisture, and it has the ability to bind in between 1,000 and 10,000 times its own weight in water (i.e. one gram binds between one and ten liters). As we age, the skin's natural ability to produce Hyaluronic Acid depletes and wrinkles start to form and deepen.

Learn More
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FAQ

What is epigenetics and how does it affect the skin?

Epigenetics explores how genes operate and how one’s lifestyle influences them, ultimately leading to signs of skin ageing. After 15 years of research, Eucerin scientists have found that these epigenetic changes determining your skin age can be reversed through targeted epigenetic skincare solutions. 

What is Eucerin’s patented Age Clock Technology?

Patented Age Clock Technology is a novel algorithm based on the epigenetic patterns of young and aged skin, which can measure the skin’s biological age. This groundbreaking technology also enabled Eucerin scientists to discover the active ingredient Epicelline®.

What age should I start using the Epigenetic Serum?

While skin ages differently depending on genetics and lifestyle, signs of ageing typically begin to appear in the late twenties and early thirties. This is why we recommend starting to use the Epigenetic Serum at this stage.

How do I know if the Epigenetic Serum is the right anti‑ageing product for me?

Eucerin Hyaluron‑Filler + Longevity Epigenetic Serum has been specially formulated to visibly reverse 10 signs of ageing and help slow down the ageing process. It is an ideal choice if you are looking for a non‑irritating yet highly effective anti‑ageing serum that targets wrinkles and fine lines, helping skin look younger than its age.

Can I apply the Epigenetic Serum to the entire face or only to specific areas?

The serum can be applied liberally to the entire face, neck and décolleté. Avoid contact with the eyes.

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Epigenetic Day Care with UV protection for ageing skin

Hyaluron-Filler + Longevity Epigenetic Day Care SPF30

Epigenetic Night Care to reverse signs of ageing

Hyaluron-Filler + Longevity Epigenetic Night Care

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Hyaluron-Filler + Longevity Epigenetic Day Care SPF30

Epigenetic Night Care to reverse signs of ageing

Hyaluron-Filler + Longevity Epigenetic Night Care

SPF 50+

Photoageing

Photoageing Control Sun Fluid SPF50

Epigenetic Day Care with UV protection for ageing skin

Hyaluron-Filler + Longevity Epigenetic Day Care SPF30

Epigenetic Night Care to reverse signs of ageing

Hyaluron-Filler + Longevity Epigenetic Night Care

SPF 50+

Photoageing

Photoageing Control Sun Fluid SPF50

4.4
from 177 reviews*
Write Review
    08/03/2026
    Hyaluron filler serum
    Lovely stuff would definitely buy again go grab some.
    Debs
    Originally posted on boots.com
    01/02/2026
    Allergy
    I had an allergic reaction! My skin turned red and was itchy!
    Ana Paula
    Originally posted on boots.com
    21/01/2026
    BEST SERUM ANTI-AGE
    I am using it first time, one week in and my skin is loving it! I combined with the dual serum anti-pigment and I can see a noticeable reduction in the wrinkles and skin texture.
    Sabrina
    Originally posted on boots.com
See all
*Reviews are not verified for authenticity
Hyaluron Filler + Longevity

Hyaluron-Filler + Longevity Epigenetic Serum

  • 4.4
    177 reviews
Skin concerns
Ageing skin
Key Benefits
  • Provides deep skin rejuvenation
  • Reduces wrinkles
  • Provides younger-looking skin
  • Visible results in 4 weeks* *Product-in-use test with 400 and 160 volunteers over 4 weeks.
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Key Ingredients

Dihydromyricetin (Epicelline®), Glycine Saponin, Enoxolone

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Size
30 ml
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